Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/115151
Title: Coagulation activation in children with sickle cell disease is associated with cerebral small vessel vasculopathy
Authors: Colombatti, Raffaella 
De Bon, Emiliano
Bertomoro, Antonella 
Casonato, Alessandra 
Pontara, Elena 
Omenetto, Elisabetta
Saggiorato, Graziella 
Steffan, Agostino
Damian, Tamara
Cella, Giuseppe
Teso, Simone 
Manara, Renzo 
Rampazzo, Patrizia 
Meneghetti, Giorgio 
Basso, Giuseppe 
Sartori, Maria Teresa 
Sainati, Laura 
Keywords Plus: VON-WILLEBRAND-FACTOR;PULMONARY-HYPERTENSION;PLASMA-LEVELS;TISSUE FACTOR;RISK;HYPERCOAGULABILITY;HYDROXYCARBAMIDE;ADAMTS-13;ADHESION;ANEMIA
Mesh headings: Anemia, Sickle Cell;Blood Coagulation;Blood Vessels;Brain
Secondary Mesh headings: Adolescent;Child;Child, Preschool;Female;Humans;Infant;Lung;Male;Thrombin
Issue Date: 2013
Publisher: PUBLIC LIBRARY SCIENCE
Journal: PloS one 
Abstract: 
Thrombotic complications in Sickle Cell Disease (SCD) arise since infancy, but the role of the coagulation system in children has been poorly explored. To determine its role in the development of clinical complications in childhood we measured coagulation and endothelial parameters in children with SCD at steady state.
URI: http://hdl.handle.net/20.500.12857/115151
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0078801
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