Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/115158
Title: A phase III study comparing secondary long-term prophylaxis versus on-demand treatment with vWF/FVIII concentrates in severe inherited von Willebrand disease
Authors: Peyvandi, Flora
Castaman, Giancarlo
Gresele, Paolo
De Cristofaro, Raimondo
Schinco, Piercarla
Bertomoro, Antonella 
Morfini, Massino
Gamba, Gabriella
Barillari, Giovanni
Jiménez-Yuste, Víctor
Königs, Cristoph
Iorio, Alfonso
Federici, Augusto B
Keywords: Factor VIII;On-demand treatment;Secondary long-term prophylaxis;Von Willebrand disease;Von Willebrand factor
Keywords Plus: REPLACEMENT THERAPY;CLINICAL-EFFICACY;FACTOR-VIII;SAFETY;DESMOPRESSIN;MANAGEMENT;FANHDI(R);DIAGNOSIS;COHORT
Mesh headings: Factor VIII;Hemorrhage;von Willebrand Diseases;von Willebrand Factor
Secondary Mesh headings: Adolescent;Adult;Drug Combinations;Female;Humans;Male;Middle Aged;Treatment Outcome;Young Adult
Issue Date: 2019
Publisher: SIMTIPRO SRL
Journal: Blood transfusion = Trasfusione del sangue 
Abstract: 
There is a lack of prospective clinical trials specifically designed to evaluate the benefits of prophylaxis with vWF/FVIII concentrates in patients with inherited von Willebrand disease (vWD). The aim of the study was to compare efficacy of secondary long-term prophylaxis (PRO) with vWF/FVIII in the prevention of bleeding episodes in severe vWD patients to standard of care (on-demand treatment; ODT).
URI: http://hdl.handle.net/20.500.12857/115158
ISSN: 17232007
DOI: 10.2450/2019.0183-18
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