Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/115421
Title: A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance
Authors: Crescenzo, Raffaella
Bianco, Francesca 
Mazzoli, Arianna
Giacco, Antonia
Liverini, Giovanna
Iossa, Susanna
Keywords: Degree of coupling;Insulin;Liver;Mitochondria
Keywords Plus: HIGH-FAT-DIET;DE-NOVO LIPOGENESIS;OXIDATIVE-PHOSPHORYLATION;LIVER-MITOCHONDRIA;HIGH-CARBOHYDRATE;SKELETAL-MUSCLE;ADIPOSE-TISSUE;FRUCTOSE;OBESITY;RATS
Mesh headings: Diet, High-Fat;Fructose;Insulin Resistance;Mitochondria, Liver
Secondary Mesh headings: Animals;Diabetes Mellitus, Type 2;Disease Models, Animal;Humans;Lipid Metabolism;Non-alcoholic Fatty Liver Disease;Obesity
Issue Date: Feb-2016
Publisher: SPRINGER HEIDELBERG
Journal: European journal of nutrition 
Abstract: 
Mitochondria are the main cellular sites devoted to ATP production and lipid oxidation. Therefore, the mitochondrial dysfunction could be an important determinant of cellular fate of circulating lipids, that accumulate in the cytoplasm, if they are not oxidized. The ectopic fat accumulation is associated with the development of insulin resistance, and a link between mitochondrial dysfunction and insulin resistance has been proposed.
URI: http://hdl.handle.net/20.500.12857/115421
ISSN: 14366207
DOI: 10.1007/s00394-015-1073-0
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