Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/115426
Title: Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models
Authors: Formisano, Luigi
Nappi, Lucia
Rosa, Roberta
Marciano, Roberta
D'Amato, Claudia
D'Amato, Valentina
Damiano, Vincenzo
Raimondo, Lucia
Iommelli, Francesca
Scorziello, Antonella
Troncone, Giancarlo
Veneziani, Bianca
Parsons, Sarah J
De Placido, Sabino
Bianco, Roberto 
Keywords Plus: TYROSINE KINASE INHIBITOR;ACQUIRED-RESISTANCE;FAMILY KINASES;ANTITUMOR-ACTIVITY;EPITHELIAL-CELLS;ZD1839 IRESSA;IN-VITRO;HER2;TRASTUZUMAB;PHOSPHORYLATION
Mesh headings: Breast Neoplasms;ErbB Receptors;Quinazolines;Receptor, ErbB-2;src-Family Kinases
Secondary Mesh headings: Animals;Antineoplastic Agents;Antineoplastic Combined Chemotherapy Protocols;Benzodioxoles;Cell Line, Tumor;Cell Movement;Cell Proliferation;Cell Survival;Drug Resistance, Neoplasm;Drug Synergism;Enzyme Activation;Enzyme Inhibitors;Female;Humans;Lapatinib;Lung Neoplasms;Mice;Mice, Inbred BALB C;Mice, Nude;Neoplasm Invasiveness;Neoplasm Transplantation;Protein Kinase Inhibitors;RNA Interference;RNA, Small Interfering;Signal Transduction;Transplantation, Heterologous
Issue Date: 5-May-2014
Publisher: BIOMED CENTRAL LTD
Journal: Breast cancer research : BCR 
Abstract: 
Src tyrosine kinase overactivation has been correlated with a poor response to human epidermal growth factor receptor 2 (HER2) inhibitors in breast cancer. To identify the mechanism by which Src overexpression sustains this resistance, we tested a panel of breast cancer cell lines either sensitive or resistant to lapatinib.
URI: http://hdl.handle.net/20.500.12857/115426
ISSN: 14655411
DOI: 10.1186/bcr3650
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