Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/115589
Title: Spindle cell oncocytoma: Report of two cases with massive bleeding and review of the literature
Authors: Billeci, Domenico 
Marton, Elisabetta 
Giordan, Enrico 
Carraro, Valentina
Ronzon, Monica 
Rossi, Sabrina 
Keywords: Bleeding macroadenoma;Oncocytoma adenohypophysis;Pituitary bleeding;Pituitary gland;Rare pituitary neoplasm;Spindle cell oncocytoma
Keywords Plus: ADENOHYPOPHYSIS REPORT;TUMOR
Mesh headings: Adenoma, Oxyphilic;Cerebral Hemorrhage;Pituitary Neoplasms
Secondary Mesh headings: Aged;Diagnosis, Differential;Diagnostic Errors;Female;Humans;Male;Middle Aged;Pituitary Gland, Anterior;Referral and Consultation
Issue Date: May-2017
Publisher: ELSEVIER SCI LTD
Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 
Abstract: 
Spindle cell oncocytoma (SCO) is a rare pituitary tumor, classified as a WHO grade I neoplasm. Due to its rarity, SCO is often preoperatively misdiagnosed as a pituitary macroadenoma. In the present study we report two recent cases of SCO, a 61-year-old male and a 65-year-old female presenting at Treviso General Hospital between March 2014 and April 2015. Tumor resection was achieved by endoscopic transsphenoidal approach but massive hemorrhagic events hampered surgery, endangering the patient's life in both cases. Both tumors featured fascicles of spindle cells with eosiniphilic cytoplasm expressing vimentin, S-100 and thyroid transcription factor-1 (TTF-1). The diagnosis of SCO was confirmed by second opinion in both cases. Extensive review of available literature, about 30 cases from 2002 to 2015, provided valuable clinical data for preoperative diagnosis and surgical removal of SCO tumors.
URI: http://hdl.handle.net/20.500.12857/115589
ISSN: 09675868
DOI: 10.1016/j.jocn.2017.02.017
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