Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/115748
Title: Gut microbiota and cancer: How gut microbiota modulates activity, efficacy and toxicity of antitumoral therapy
Authors: Gori, Stefania 
Inno, Alessandro 
Belluomini, Lorenzo
Bocus, Paolo 
Bisoffi, Zeno 
Russo, Antonio
Arcaro, Guido
Keywords: 5-Fluorouracil;Cisplatin;Cyclophosphamide;Gemcitabine;Immune checkpoint inhibitors;Irinotecan;Microbiota;Tyrosine kinase inhibitors
Keywords Plus: D-METHIONINE;FUSOBACTERIUM-NUCLEATUM;INTESTINAL MUCOSITIS;COMBINED NIVOLUMAB;5-FLUOROURACIL;APOPTOSIS;CARCINOGENESIS;GEMCITABINE;IPILIMUMAB;DOCETAXEL
Mesh headings: Antineoplastic Agents;Gastrointestinal Microbiome;Neoplasms
Secondary Mesh headings: Animals;Fecal Microbiota Transplantation;Humans;Immunotherapy
Issue Date: Nov-2019
Publisher: ELSEVIER SCIENCE INC
Journal: Critical reviews in oncology/hematology 
Abstract: 
Gut microbiota is involved in gastrointestinal carcinogenesis. Also, it modulates the activity, efficacy and toxicity of several chemotherapy agents, such as gemcitabine, cyclophosphamide, irinotecan, cisplatin and 5-Fluorouracil, and target therapy, such as tyrosine kinase inhibitors. More recently, accumulating data suggest that the composition of gut microbiota may also affect efficacy and toxicity of cancer immunotherapy. Therefore, the manipulation of gut microbiota through antibiotics, probiotics, prebiotics or fecal transplantation has been investigating with the aim to improve efficacy and mitigate toxicity of anticancer drugs.
URI: http://hdl.handle.net/20.500.12857/115748
ISSN: 10408428
DOI: 10.1016/j.critrevonc.2019.09.003
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