Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/115781
Title: The sympathetic nervous system and catecholamines metabolism in obstructive sleep apnoea
Authors: Bisogni, Valeria 
Pengo, Martino F
Maiolino, Giuseppe 
Rossi, Gian Paolo 
Keywords: Obstructive sleep apnoea (OSA);cardiovascular risk (CV risk);catecholamines (CAs);sympathetic nervous system (SNS)
Keywords Plus: HEART-RATE-VARIABILITY;POSITIVE AIRWAY PRESSURE;CARDIAC AUTONOMIC CONTROL;BLOOD-PRESSURE;O-METHYLTRANSFERASE;MECHANISMS;RESPONSES;HYPOXIA;MALES;CPAP
Issue Date: Feb-2016
Publisher: AME PUBL CO
Journal: Journal of thoracic disease 
Abstract: 
Obstructive sleep apnoea (OSA) is the most common sleep disorder of breathing in middle-aged and overweight subjects. It features recurrent episodes of upper airway total (apnoea) o partial (hypopnea) collapse during sleep, which are associated with a reduction in blood oxygen saturation and with arousal from sleep to re-establish airway patency. An association of OSA with dysregulation of the autonomous nervous system (ANS) and altered catecholamines (CAs) metabolism has been contended for years. However, the pathophysiology mechanisms underlying these alterations remain to be fully clarified. Nonetheless, these alterations are deemed to play a key pathogenic role in the established association of OSA with several conditions besides arterial hypertension (HT), including coronary artery disease, stroke, and, more in general, with increased risk of cardiovascular (CV) events. Hence, in this review we will analyse the relationship between the sleep disturbances associated with OSA and the altered function of the ANS, including CAs metabolism.
URI: http://hdl.handle.net/20.500.12857/115781
ISSN: 2072-1439
DOI: 10.3978/j.issn.2072-1439.2015.11.14
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