Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/115819
Title: MicroRNA-27a Contributes to Rhabdomyosarcoma Cell Proliferation by Suppressing RARA and RXRA
Authors: Tombolan, Lucia 
Zampini, Matteo 
Casara, Silvia 
Boldrin, Elena
Zin, Angelica 
Bisogno, Gianni 
Rosolen, Angelo 
De Pittà, Cristiano
Lanfranchi, Gerolamo 
Keywords Plus: TRANS-RETINOIC ACID;ACUTE PROMYELOCYTIC LEUKEMIA;CHRONIC LYMPHOCYTIC-LEUKEMIA;GENE-EXPRESSION SIGNATURE;BREAST-CANCER CELLS;EMBRYONAL RHABDOMYOSARCOMA;ALVEOLAR RHABDOMYOSARCOMA;TRANSCRIPTION FACTORS;CHILDHOOD RHABDOMYOSARCOMA;ONCOGENIC MICRORNA-27A
Mesh headings: Cell Proliferation;MicroRNAs;Receptors, Retinoic Acid;Retinoid X Receptor alpha;Rhabdomyosarcoma
Secondary Mesh headings: Cell Line, Tumor;Flow Cytometry;Gene Expression Profiling;Gene Expression Regulation, Neoplastic;HEK293 Cells;Humans;RNA, Messenger;Real-Time Polymerase Chain Reaction;Retinoic Acid Receptor alpha
Issue Date: 2015
Publisher: PUBLIC LIBRARY SCIENCE
Journal: PloS one 
Abstract: 
Rhabdomyosarcomas (RMS) are rare but very aggressive childhood tumors that arise as a consequence of a regulatory disruption in the growth and differentiation pathways of myogenic precursor cells. According to morphological criteria, there are two major RMS subtypes: embryonal RMS (ERMS) and alveolar RMS (ARMS) with the latter showing greater aggressiveness and metastatic potential with respect to the former. Efforts to unravel the complex molecular mechanisms underlying RMS pathogenesis and progression have revealed that microRNAs (miRNAs) play a key role in tumorigenesis.
URI: http://hdl.handle.net/20.500.12857/115819
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0125171
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