Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/115839
Title: Evidence of hydroxyurea activity in children with pretreated desmoid-type fibromatosis: A new option in the armamentarium of systemic therapies
Authors: Ferrari, Andrea
Orbach, Daniel
Affinita, Maria Carmen 
Chiaravalli, Stefano
Corradini, Nadege
Meazza, Cristina
Bisogno, Gianni 
Casanova, Michela
Keywords: aggressive fibromatosis;chemotherapy;children;desmoid-type fibromatosis;hydroxyurea;new drug
Keywords Plus: EFFICACY;METHOTREXATE;ADOLESCENTS;MANAGEMENT;TUMORS
Mesh headings: Antineoplastic Agents;Fibromatosis, Aggressive;Hydroxyurea;Neoplasm Recurrence, Local
Secondary Mesh headings: Adolescent;Adult;Child;Child, Preschool;Disease Progression;Female;Follow-Up Studies;France;Humans;Incidence;Infant;Male;Prognosis;Young Adult
Issue Date: 2019
Publisher: WILEY
Journal: Pediatric blood & cancer 
Abstract: 
The treatment paradigm in desmoid-type fibromatosis (DF) has changed in recent years from a surgery-based strategy to a multidisciplinary approach that includes systemic therapies. Among various medical therapies, hydroxyurea has been considered of potential interest. This case series summarizes the experience gained at four centers using hydroxyurea in relapsing DF.
URI: http://hdl.handle.net/20.500.12857/115839
ISSN: 15455009
DOI: 10.1002/pbc.27472
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