Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/116002
Title: Toothbrushes may convey bacteria to the cystic fibrosis lower airways
Authors: Passarelli Mantovani, Rebeca
Sandri, Angela 
Boaretti, Marzia 
Grilli, Alessandra
Volpi, Sonia 
Melotti, Paola 
Burlacchini, Gloria
Lleò, Maria M
Signoretto, Caterina 
Keywords: Bacterial oral reservoirs;cystic fibrosis;oral hygiene;saliva;sputum;toothbrush care
Keywords Plus: FIELD GEL-ELECTROPHORESIS;PSEUDOMONAS-AERUGINOSA;COLONIZATION;CONTAMINATION;INFECTION;DECLINE;DISEASE;SPUTUM;LOCUS
Issue Date: 2019
Publisher: TAYLOR & FRANCIS LTD
Journal: Journal of oral microbiology 
Abstract: 
Recent findings indicate that the oral cavity acts as a bacterial reservoir and might contribute to the transmission of bacteria to the lower airways. Control of a potentially pathogenic microbiota might contribute to prevent the establishment of chronic infection in cystic fibrosis. We evaluated the presence of CF microorganisms in saliva and toothbrushes of CF patients and verify their possible transmission to lower airways. Methods: We assessed the presence of P. aeruginosa, S. aureus, S. maltophilia, A. xylosoxidans, S. marcescens, and yeasts in saliva, toothbrushes and sputum of 38 CF patients and assessed the clonal identity of the strains occurring contemporary in multiple sites by PFGE. Results: At least one of the investigated species was isolated from 60 saliva samples and 23 toothbrushes. S. aureus was the most abundant species, followed by Candida spp. 31 patients contemporary had the same species in sputum and saliva/toothbrush: in most cases, clonal identity of the strains among the different sites was confirmed. Conclusion: Toothbrushes may be sources of oral contamination and might act as reservoirs favoring transmission of potentially pathogenic microorganisms from the environment to the oral cavity and eventually to the LAW. Oral hygiene and toothbrush care are important strategies to prevent CF lung infections.
URI: http://hdl.handle.net/20.500.12857/116002
ISSN: 2000-2297
DOI: 10.1080/20002297.2019.1647036
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