Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/116060
Title: Trabectedin Drug Holiday and Rechallenge in Soft Tissue Sarcomas: Report of 4 Cases and Literature Review
Authors: Pierantoni, Francesco
Maruzzo, Marco 
Brunello, Antonella 
Chiusole, Benedetta 
Pusole, Grazia
Bezzon, Elisabetta
Basso, Umberto 
Zagonel, Vittorina 
Keywords: Trabectedin;drug holiday;maintenance therapy;re-challenge;soft-tissue sarcoma
Keywords Plus: RENAL-CELL CARCINOMA;PHASE-II;ANTITUMOR-ACTIVITY;LIPOSARCOMA;LEIOMYOSARCOMA;PATIENT
Issue Date: 2019
Publisher: FRONTIERS MEDIA SA
Journal: Frontiers in oncology 
Abstract: 
Soft tissue sarcomas are rare neoplasms, with a high mortality rate. Few drugs are available for the treatment of patients affected by metastatic sarcomas, who still have a 5-years survival rate lower than 20%. However, some of the more recent therapies can obtain long lasting responses in a portion of patients, such as Trabectedin. We analyzed four such cases treated at our Institute after progression to an anthracycline based regimen. In each case a therapeutic pause was proposed after at least 6 months of therapy with Trabectedin and in three out of four patients a re-challenge was proposed at progression, achieving again disease control or response. In two cases oligo-progressive sites were treated with localized therapies as stereotactic radiotherapy, delaying the systemic treatment re-start. In this article the reports of the patients involved are presented with a concise review of the relevant literature. Our findings support the favorable safety profile of Trabectedin and the feasibility of drug holidays, which should be at least discussed with the patient.
URI: http://hdl.handle.net/20.500.12857/116060
ISSN: 2234-943X
DOI: 10.3389/fonc.2019.00553
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