Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/116334
Title: MRI reveals therapeutical efficacy of stem cells: An experimental study on the SOD1(G93A) animal model
Authors: Bontempi, Pietro 
Busato, Alice 
Bonafede, Roberta 
Schiaffino, Lorenzo 
Scambi, Ilaria 
Sbarbati, Andrea 
Mariotti, Raffaella 
Marzola, Pasquina 
Keywords: MRI;SOD1(G93A);amyotrophic lateral sclerosis;mesenchymal stem cells;voxel-based morphometry
Keywords Plus: AMYOTROPHIC-LATERAL-SCLEROSIS;TRANSGENIC MOUSE MODEL;MOTOR-NEURON DEGENERATION;VOXEL-BASED MORPHOMETRY;DISEASE PROGRESSION;SKELETAL-MUSCLE;BRAIN ATROPHY;ALS;MICE;PATHOLOGY
Mesh headings: Image Processing, Computer-Assisted;Magnetic Resonance Imaging;Stem Cell Transplantation;Stem Cells;Superoxide Dismutase-1
Secondary Mesh headings: Animals;Anisotropy;Behavior, Animal;Biomarkers;Brain;Brain Stem;Diffusion Tensor Imaging;Disease Models, Animal;Disease Progression;Female;Humans;Male;Mice;Phenotype;Promoter Regions, Genetic;Superoxide Dismutase;Transgenes
Issue Date: Jan-2018
Publisher: WILEY
Journal: Magnetic resonance in medicine 
Abstract: 
The first part of the experiment identifies and validates MRI biomarkers distinctive of the disease progression in the transgenic superoxide dismutase gene (SOD1(G93A)) animal model. The second part assesses the efficacy of a mesenchymal stem cell-based therapy through the MRI biomarkers previously defined.
URI: http://hdl.handle.net/20.500.12857/116334
ISSN: 07403194
DOI: 10.1002/mrm.26685
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