Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/116339
Title: Surface plasmon resonance based on molecularly imprinted nanoparticles for the picomolar detection of the iron regulating hormone Hepcidin-25
Authors: Cenci, Lucia 
Andreetto, Erika
Vestri, Ambra 
Bovi, Michele 
Barozzi, Mario
Iacob, Erica
Busato, Mirko 
Castagna, Annalisa 
Girelli, Domenico 
Bossi, Alessandra Maria 
Keywords: Biosensor;Hepcidin;Iron metabolism;Molecularly imprinted polymers;Nanoparticles;Surface plasmon resonance
Keywords Plus: SCIENCE-AND-TECHNOLOGY;POLYMER NANOPARTICLES;ANTIMICROBIAL ACTIVITY;OPTICAL-FIBER;RECOGNITION;BINDING;SENSOR;QUANTIFICATION;PROTEINS;AFFINITY
Mesh headings: Hepcidins;Molecular Imprinting;Nanoparticles;Surface Plasmon Resonance
Secondary Mesh headings: Humans;Iron;Limit of Detection
Issue Date: 27-Aug-2015
Publisher: BMC
Journal: Journal of nanobiotechnology 
Abstract: 
Molecularly imprinted polymer (MIP) technique is a powerful mean to produce tailor made synthetic recognition sites. Here precipitation polymerization was exploited to produce a library of MIP nanoparticles (NPs) targeting the N terminus of the hormone Hepcidin-25, whose serum levels correlate with iron dis-metabolisms and doping. Biotinylated MIP NPs were immobilized to NeutrAvidin™ SPR sensor chip. The response of the MIP NP sensor to Hepcidin-25 was studied.
URI: http://hdl.handle.net/20.500.12857/116339
ISSN: 1477-3155
DOI: 10.1186/s12951-015-0115-3
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