Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/116496
Title: Animal models of cholangiocarcinoma: What they teach us about the human disease
Authors: Cadamuro, Massimiliano 
Brivio, Simone
Stecca, Tommaso 
Kaffe, Eleanna
Mariotti, Valeria 
Milani, Chiara 
Fiorotto, Romina
Spirli, Carlo
Strazzabosco, Mario
Fabris, Luca
Keywords: Genetically engineered mouse models;Primary liver cancer;Syngeneic models;Toxic models;Xenotransplantation
Keywords Plus: VIVERRINI-ASSOCIATED CHOLANGIOCARCINOMA;CANCER-ASSOCIATED FIBROBLASTS;GROWTH-FACTOR RECEPTOR;BILE-DUCT;INTRAHEPATIC CHOLANGIOCARCINOMA;MOUSE MODEL;CELL-PROLIFERATION;MOLECULAR-MECHANISMS;INDUCED APOPTOSIS;GENE-EXPRESSION
Mesh headings: Bile Duct Neoplasms;Cholangiocarcinoma;Disease Models, Animal
Secondary Mesh headings: Animals;Humans
Issue Date: 2018
Publisher: ELSEVIER MASSON, CORPORATION OFFICE
Journal: Clinics and research in hepatology and gastroenterology 
Abstract: 
Despite recent advances, pathogenesis of cholangiocarcinoma, a highly lethal cancer, remains enigmatic. Furthermore, treatment options are still limited and often disappointing. For this reason, in the last few years there has been a mounting interest towards the generation of experimental models able to reproduce the main features associated with this aggressive behavior. Toxic and infestation-induced, genetically engineered and cell implantation rodent models have been generated, contributing to a deeper understanding of the complex cell biology of the tumor, sustained by multiple cell interactions and driven by a huge variety of molecular perturbations. Herein, we will overview the most relevant animal models of biliary carcinogenesis, highlighting the methodological strategy, the molecular, histological and clinical phenotypes consistent with the human condition, their particular strengths and weaknesses and the novel therapeutic approaches that have been developed.
URI: http://hdl.handle.net/20.500.12857/116496
ISSN: 22107401
DOI: 10.1016/j.clinre.2018.04.008
Appears in Collections:Articles

Show full item record

PubMed Central
Citations 50

7
Last Week
1
Last month
checked on Jun 23, 2021

SCOPUSTM   
Citations 50

8
checked on Sep 1, 2020

WEB OF SCIENCETM
Citations

13
checked on Dec 4, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.