Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/116500
Title: Platelet-derived growth factor-D enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinoma
Authors: Cadamuro, Massimiliano 
Brivio, Simone
Mertens, Joachim
Vismara, Marta 
Moncsek, Anja
Milani, Chiara 
Fingas, Christian
Cristina Malerba, Maria
Nardo, Giorgia
Dall'Olmo, Luigi 
Milani, Eleonora 
Mariotti, Valeria 
Stecca, Tommaso 
Massani, Marco 
Spirli, Carlo
Fiorotto, Romina
Indraccolo, Stefano 
Strazzabosco, Mario
Fabris, Luca
Keywords: Cholangiocytes;Lymphatic endothelial cells;Tumor reactive stroma;VEGF-C;VEGFR3
Keywords Plus: CANCER-ASSOCIATED FIBROBLASTS;VEGF-C;RECEPTOR-BETA;PROGRESSION;METASTASIS;EXPRESSION;CARCINOMA;BB;MECHANISMS;INDUCTION
Issue Date: Apr-2019
Publisher: ELSEVIER SCIENCE BV
Journal: Journal of hepatology 
Abstract: 
In cholangiocarcinoma, early metastatic spread via lymphatic vessels often precludes curative therapies. Cholangiocarcinoma invasiveness is fostered by an extensive stromal reaction, enriched in cancer-associated fibroblasts (CAFs) and lymphatic endothelial cells (LECs). Cholangiocarcinoma cells recruit and activate CAFs by secreting PDGF-D. Herein, we investigated the role of PDGF-D and liver myofibroblasts in promoting lymphangiogenesis in cholangiocarcinoma.
URI: http://hdl.handle.net/20.500.12857/116500
ISSN: 01688278
DOI: 10.1016/j.jhep.2018.12.004
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