Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/116503
Title: Diagnostic and prognostic biomarkers in cholangiocarcinoma
Authors: Macias, Rocio I R
Kornek, Miroslaw
Rodrigues, Pedro M
Paiva, Nuno A
Castro, Rui E
Urban, Sabine
Pereira, Stephen P
Cadamuro, Massimiliano 
Rupp, Christian
Loosen, Sven H
Luedde, Tom
Banales, Jesus M
Keywords: CCA prognosis;biliary cancer;biomarker;early diagnosis;omics
Keywords Plus: CIRCULATING TUMOR-CELLS;PRIMARY SCLEROSING CHOLANGITIS;INTRAHEPATIC CHOLANGIOCARCINOMA;EXTRACELLULAR VESICLES;GROWTH-FACTOR;POOR-PROGNOSIS;SERUM CA19-9;CLINICOPATHOLOGICAL SIGNIFICANCE;HEPATOCELLULAR-CARCINOMA;CLINICAL-SIGNIFICANCE
Mesh headings: Bile Duct Neoplasms;Biomarkers, Tumor;Cholangiocarcinoma
Secondary Mesh headings: Biopsy;Early Diagnosis;Humans;Prognosis;Proteomics
Issue Date: 2019
Publisher: WILEY
Journal: Liver international : official journal of the International Association for the Study of the Liver 
Abstract: 
The high mortality rate of cholangiocarcinoma (CCA) is due, in part, to the lack of non-invasive approaches able to accurately detect this silent tumour at early stages, when therapeutic options can be potentially curative or may at least increase the overall survival of patients. The fact that the majority of CCA tumours are not linked to any known aetiological factor highly compromises the monitoring of patients at risk for tumour development and also their early diagnosis. Combination of clinical/biochemical features, imaging techniques and analysis of non-specific tumour biomarkers in serum are commonly used to help in the diagnosis of CCA, but tumour biopsy is usually required to confirm the diagnosis. Moreover, no prognostic biomarkers are currently used in the clinical setting, deserving more innovative research, and international validation and consensus. Important efforts have been made in the last few years to identify accurate non-invasive biomarkers, by using innovative techniques and high-throughput omics technologies. This review summarizes and discusses the advances in the investigation of novel diagnostic and prognostic biomarkers in CCA and envisions the future directions in this field of research.
URI: http://hdl.handle.net/20.500.12857/116503
ISSN: 14783223
DOI: 10.1111/liv.14090
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