Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/116752
Title: Triple-negative vimentin-positive heterogeneous feline mammary carcinomas as a potential comparative model for breast cancer
Authors: Caliari, Diego 
Zappulli, Valentina
Rasotto, Roberta
Cardazzo, Barbara 
Frassineti, Federica
Goldschmidt, Michael H
Castagnaro, Massimo
Keywords: Feline;Human breast cancer;Mammary tumor;Markers;Triple-negative;Vimentin
Keywords Plus: HIGH EXPRESSION;BETA-CATENIN;E-CADHERIN;TUMOR;BASAL;PROGNOSIS;RECOMMENDATIONS;CLASSIFICATION;CYTOKERATINS;TRANSLATION
Mesh headings: Breast Neoplasms;Cat Diseases;Gene Expression Regulation, Neoplastic;Mammary Neoplasms, Animal;Receptors, Cell Surface;Vimentin
Secondary Mesh headings: Animals;Cats;Female;Humans
Issue Date: 25-Sep-2014
Publisher: BMC
Journal: BMC veterinary research 
Abstract: 
Human breast cancer is a heterogeneous disease classified by molecular subtyping into luminal A, luminal B, HER2-overexpressing, basal-like, claudin-low and normal-breast like. The routinely applied and standardized immunohistochemical-based surrogates of this classification group together the last three entities as triple-negative breast cancer (TNBCs) that show the most diverse and complex heterogeneity and represent a therapeutic challenge. In the present work 156 feline mammary lesions consisting of feline mammary carcinomas (FMCs), benign neoplasms, and hyperplastic/dysplastic tissues were evaluated histologically and by immunohistochemistry for expression of basal and luminal cytokeratins (CK), vimentin, alpha-smooth muscle actin, calponin, estrogen receptor (ER) alpha (a), and progesterone receptor (PR). Thirty-seven FMCs with 27 matched non-neoplastic controls were also investigated for gene expression of ERa, ER beta, PR, and HER2.
URI: http://hdl.handle.net/20.500.12857/116752
DOI: 10.1186/s12917-014-0185-8
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