Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/116754
Title: 1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma
Authors: D'Alessandro, Giuseppina
Quaglio, Deborah
Monaco, Lucia
Lauro, Clotilde
Ghirga, Francesca
Ingallina, Cinzia
De Martino, Michela
Fucile, Sergio
Porzia, Alessandra
Di Castro, Maria Amalia
Bellato, Federica
Mastrotto, Francesca 
Mori, Mattia
Infante, Paola
Turano, Paola
Salmaso, Stefano 
Caliceti, Paolo 
Di Marcotullio, Lucia
Botta, Bruno
Ghini, Veronica
Limatola, Cristina
Keywords: 1H-NMR spectroscopy;Glioma;Hh pathway;Isoflavones;Metabolomics
Keywords Plus: HEDGEHOG PATHWAY;CANCER;EXPRESSION;PHENOTYPE;THERAPY;LACTATE;PROTEIN;TUMORS;GLI1
Issue Date: 2019
Publisher: BMC
Journal: Cell communication and signaling : CCS 
Abstract: 
Glioma is the most common and primary brain tumors in adults. Despite the available multimodal therapies, glioma patients appear to have a poor prognosis. The Hedgehog (Hh) signaling is involved in tumorigenesis and emerged as a promising target for brain tumors. Glabrescione B (GlaB) has been recently identified as the first direct inhibitor of Gli1, the downstream effector of the pathway.
URI: http://hdl.handle.net/20.500.12857/116754
DOI: 10.1186/s12964-019-0421-8
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