Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/118743
Title: Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells
Authors: Marchiori, Chiara 
Scarpa, Melania 
Kotsafti, Andromachi 
Morgan, Susan
Fassan, Matteo 
Guzzardo, Vincenza 
Porzionato, Andrea 
Angriman, Imerio 
Ruffolo, Cesare 
Sut, Stefania 
Dall'Acqua, Stefano 
Bardini, Romeo 
De Caro, Raffaele 
Castoro, Carlo 
Scarpa, Marco 
Castagliuolo, Ignazio 
Keywords: CD80;Colorectal cancer;Dysplasia;Immune surveillance
Keywords Plus: COLORECTAL-CANCER;ANTIOXIDANT ACTIVITY;HYDROGEN-PEROXIDE;GENE-EXPRESSION;DOWN-REGULATION;T-CELLS;B7-1;ADENOMA;MUCOSA;PROGRESSION
Mesh headings: B7-1 Antigen;Colonic Neoplasms;Precancerous Conditions;STAT3 Transcription Factor
Secondary Mesh headings: Animals;Carcinogenesis;Colon;Epithelial Cells;Flow Cytometry;Gene Expression Regulation, Neoplastic;Humans;Immunophenotyping;Intestinal Mucosa;Mice;Mice, Knockout;Oxidative Stress;Primary Cell Culture;Signal Transduction;p38 Mitogen-Activated Protein Kinases
Issue Date: 9-May-2019
Publisher: BMC
Journal: Journal of experimental & clinical cancer research : CR 
Abstract: 
One of the most potent costimulatory molecules involved in the recognition and killing of tumor cells is CD80. However, its role and the molecular mechanisms regulating its expression in sporadic colorectal carcinogenesis remain elusive. Here, we provide evidence for CD80 overexpression in human colon epithelial cells derived from preneoplastic mucosa.
URI: http://hdl.handle.net/20.500.12857/118743
ISSN: 1756-9966
DOI: 10.1186/s13046-019-1205-0
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