Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/121509
Title: Cortisol and cortisone ratio in urine: LC-MS/MS method validation and preliminary clinical application
Authors: Antonelli, Giorgia 
Artusi, Carlo
Marinova, Mariela
Brugnolo, Laura
Zaninotto, Martina 
Scaroni, Carla 
Gatti, Rosalba 
Mantero, Franco 
Plebani, Mario 
Keywords: Cortisol;Cortisone;Liquid chromatography;Ratio;Reference range;Tandem mass spectrometry
Keywords Plus: TANDEM MASS-SPECTROMETRY;PERFORMANCE LIQUID-CHROMATOGRAPHY;DIAGNOSIS;SPECIFICITY;PLASMA;SERUM
Mesh headings: Chromatography, High Pressure Liquid;Cortisone;Hydrocortisone;Tandem Mass Spectrometry;Urinalysis
Secondary Mesh headings: Adolescent;Adult;Aged;Aged, 80 and over;Child;Female;Humans;Male;Middle Aged;Mineralocorticoid Excess Syndrome, Apparent;Reference Values;Solid Phase Extraction;Young Adult
Issue Date: Feb-2014
Publisher: WALTER DE GRUYTER GMBH
Journal: Clinical chemistry and laboratory medicine 
Abstract: 
The determination of urinary cortisol/cortisone ratio is of clinical utility in cases of Cushing's syndrome, apparent mineralocorticoid excess, and also provides information on 11β-hydroxysteroid dehydrogenase (11β-HSD) type 2 activity. It is therefore of utmost importance to ensure accurate cortisol and cortisone measurement and establish appropriate reference ranges.
URI: http://hdl.handle.net/20.500.12857/121509
ISSN: 14346621
DOI: 10.1515/cclm-2013-0471
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