Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/123936
Title: Could molecular assessment of calcium metabolism be a useful tool to early screen patients at risk for pre-eclampsia complicated pregnancy? Proposal and rationale
Authors: Gizzo, Salvatore 
Noventa, Marco 
Di Gangi, Stefania 
Saccardi, Carlo 
Cosmi, Erich 
Nardelli, Giovanni Battista 
Plebani, Mario 
Keywords: Bone metabolism;calcium supplementation;pre-eclampsia;pregnancy outcome;serum biochemical profile
Keywords Plus: UTERINE ARTERY DOPPLER;BONE TURNOVER;SUPPLEMENTATION;PREVENTION;PREDICTION;EXPRESSION;MARKERS
Mesh headings: Calcium;Pre-Eclampsia
Secondary Mesh headings: Early Diagnosis;Evidence-Based Medicine;Female;Humans;Pregnancy;Risk
Issue Date: Jun-2015
Publisher: WALTER DE GRUYTER GMBH
Journal: Clinical chemistry and laboratory medicine 
Abstract: 
One of the most frequent causes of maternal and perinatal morbidity is represented by hypertensive disorders during pregnancy. Women at high risk must be subjected to a more intensive antenatal surveillance and prophylactic treatments. Many genetic risk factors, clinical features and biomarkers have been proposed but none of these seems able to prevent pre-eclampsia onset. English literature review of manuscripts focused on calcium intake and hypertensive disorders during pregnancy was performed. We performed a critical analysis of evidences about maternal calcium metabolism pattern in pregnancy analyzing all possible bias affecting studies. Calcium supplementation seems to give beneficial effects on women with low calcium intake. Some evidence reported that calcium supplementation may drastically reduce the percentage of pre-eclampsia onset consequently improving the neonatal outcome. Starting from this evidence, it is intuitive that investigations on maternal calcium metabolism pattern in first trimester of pregnancy could represent a low cost, large scale tool to screen pregnant women and to identify those at increased risk of pre-eclampsia onset. We propose a biochemical screening of maternal calcium metabolism pattern in first trimester of pregnancy to discriminate patients who potentially may benefit from calcium supplementation. In a second step we propose to randomly allocate the sub-cohort of patients with calcium metabolism disorders in a treatment group (calcium supplementation) or in a control group (placebo) to define if calcium supplementation may represent a dietary mean to reduce pre-eclampsia onset and to improve pregnancy outcome.
URI: http://hdl.handle.net/20.500.12857/123936
ISSN: 14346621
DOI: 10.1515/cclm-2014-0693
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