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|Title:||Pigmented trichoblastoma developed in a sebaceous nevus: HRAS mutation as a common molecular driver||Authors:||Saraggi, Deborah
|Keywords:||HRAS;Pigmented trichoblastoma;Sebaceous nevus||Mesh headings:||Biomarkers, Tumor;Head and Neck Neoplasms;Mutation;Nevus, Sebaceous of Jadassohn;Proto-Oncogene Proteins p21(ras);Scalp;Sebaceous Gland Neoplasms||Secondary Mesh headings:||Adult;DNA Mutational Analysis;Female;GTP Phosphohydrolases;Genetic Predisposition to Disease;Humans;Immunohistochemistry;Membrane Proteins;Phenotype;Proto-Oncogene Proteins B-raf||Issue Date:||Jul-2017||Publisher:||ELSEVIER GMBH, URBAN & FISCHER VERLAG||Journal:||Pathology, research and practice||Abstract:||
A 40-year-old woman presented with a pigmented nodule on a previously existing yellowish, verrucous plaque on the scalp. The histological diagnosis was consistent with a pigmented trichoblastoma developed within a sebaceous nevus (SN). A multigene hotspot mutational profiling of the BRAF, NRAS, HRAS and KRAS genes was carried out, and a shared G13R HRAS mutation in both the trichoblastoma and the sebaceous nevus components was found. These data support a common molecular landscape of the two lesions.
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