Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/124551
Title: Pigmented trichoblastoma developed in a sebaceous nevus: HRAS mutation as a common molecular driver
Authors: Saraggi, Deborah 
Salmaso, Roberto 
Valentini, Elisa 
Munari, Giada 
Vindigni, Vincenzo 
Rugge, Massimo 
Fassan, Matteo 
Cerroni, Lorenzo
Keywords: HRAS;Pigmented trichoblastoma;Sebaceous nevus
Mesh headings: Biomarkers, Tumor;Head and Neck Neoplasms;Mutation;Nevus, Sebaceous of Jadassohn;Proto-Oncogene Proteins p21(ras);Scalp;Sebaceous Gland Neoplasms
Secondary Mesh headings: Adult;DNA Mutational Analysis;Female;GTP Phosphohydrolases;Genetic Predisposition to Disease;Humans;Immunohistochemistry;Membrane Proteins;Phenotype;Proto-Oncogene Proteins B-raf
Issue Date: Jul-2017
Publisher: ELSEVIER GMBH, URBAN & FISCHER VERLAG
Journal: Pathology, research and practice 
Abstract: 
A 40-year-old woman presented with a pigmented nodule on a previously existing yellowish, verrucous plaque on the scalp. The histological diagnosis was consistent with a pigmented trichoblastoma developed within a sebaceous nevus (SN). A multigene hotspot mutational profiling of the BRAF, NRAS, HRAS and KRAS genes was carried out, and a shared G13R HRAS mutation in both the trichoblastoma and the sebaceous nevus components was found. These data support a common molecular landscape of the two lesions.
URI: http://hdl.handle.net/20.500.12857/124551
ISSN: 03440338
DOI: 10.1016/j.prp.2017.03.012
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