Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/124669
Title: Gyrification brain abnormalities as predictors of outcome in anorexia nervosa
Authors: Favaro, Angela 
Tenconi, Elena 
Degortes, Daniela 
Manara, Renzo 
Santonastaso, Paolo 
Keywords: MRI;anorexia nervosa;brain gyrification;cortical folding;outcome
Keywords Plus: HUMAN CEREBRAL-CORTEX;OBSTETRIC COMPLICATIONS;FUNCTIONAL CONNECTIVITY;EATING-DISORDERS;PERINATAL FACTORS;CENTRAL COHERENCE;SCHIZOPHRENIA;RISK;METAANALYSIS;HANDEDNESS
Mesh headings: Anorexia Nervosa;Brain;Brain Mapping
Secondary Mesh headings: Age of Onset;Female;Functional Laterality;Humans;Image Processing, Computer-Assisted;Longitudinal Studies;Magnetic Resonance Imaging;Monte Carlo Method;Predictive Value of Tests;Severity of Illness Index;Statistics as Topic
Issue Date: Dec-2015
Publisher: WILEY
Journal: Human brain mapping 
Abstract: 
Gyrification brain abnormalities are considered a marker of early deviations from normal developmental trajectories and a putative predictor of poor outcome in psychiatric disorders. The aim of this study was to explore cortical folding morphology in patients with anorexia nervosa (AN). A MRI brain study was conducted on 38 patients with AN, 20 fully recovered patients, and 38 healthy women. Local gyrification was measured with procedures implemented in FreeSurfer. Vertex-wise comparisons were carried out to compare: (1) AN patients and healthy women; (2) patients with a full remission at a 3-year longitudinal follow-up assessment and patients who did not recover. AN patients exhibited significantly lower gyrification when compared with healthy controls. Patients with a poor 3-year outcome had significantly lower baseline gyrification when compared to both healthy women and patients with full recovery at follow-up, even after controlling for the effects of duration of illness and gray matter volume. No significant correlation has been found between gyrification, body mass index, amount of weight loss, onset age, and duration of illness. Brain gyrification significantly predicted outcome at follow-up even after controlling for the effects of duration of illness and other clinical prognostic factors. Although the role of starvation in determining our findings cannot be excluded, our study showed that brain gyrification might be a predictor of outcome in AN. Further studies are needed to understand if brain gyrification abnormalities are indices of early neurodevelopmental alterations, the consequence of starvation, or the interaction between both factors.
URI: http://hdl.handle.net/20.500.12857/124669
ISSN: 10659471
DOI: 10.1002/hbm.22998
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