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|Title:||No evidence for an association of vitamin D deficiency and migraine: a systematic review of the literature||Authors:||Lippi, Giuseppe
|Keywords Plus:||25-HYDROXYVITAMIN D;HEADACHE;PREVALENCE;GUIDELINES;CALCIUM;SKIN||Mesh headings:||Migraine Disorders;Vitamin D Deficiency||Secondary Mesh headings:||Adult;Cross-Sectional Studies;Female;Humans;Male;Middle Aged||Issue Date:||2014||Publisher:||HINDAWI LTD||Journal:||BioMed research international||Abstract:||
Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Science using the keywords "migraine" and "vitamin D," "25OH-D" "cholecalciferol," "ergocalciferol," with no language or date restriction. The electronic search allowed identifying seven studies (3 observational, 2 cross-sectional, and 2 case reports). The two case reports, including four women, showed favourable effects of vitamin D supplementation on migraine severity, but these studies were small and not placebo controlled. As regards the three observational studies, vitamin D deficiency was observed in 13.2 to 14.8% of migraine patients, and these rates do not differ from those reported in the general population (i.e., vitamin D deficiency between 22 and 42%). The results of the two cross-sectional studies are even more controversial, since no association was found between vitamin D status and migraine in both trials. In conclusion, the current evidence suggests that the association between migraine and vitamin D lacks reliable scientific support.
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