Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/126994
Title: Immunoglobulin E (IgE) and ischemic heart disease. Which came first, the chicken or the egg?
Authors: Lippi, Giuseppe 
Cervellin, Gianfranco 
Sanchis-Gomar, Fabian
Keywords: Acute myocardial infarction;IgE;immune system;immunoglobulin E;ischemic heart disease
Keywords Plus: RECURRENT INFECTION SYNDROME;CORONARY-ARTERY ANEURYSMS;MAST-CELL GRANULES;MYOCARDIAL-INFARCTION;CARDIOVASCULAR-DISEASE;ALLERGIC ANGINA;KOUNIS-SYNDROME;FOAM CELLS;E RESPONSE;ATHEROSCLEROSIS
Mesh headings: Immunoglobulin E;Mast Cells;Myocardial Ischemia
Secondary Mesh headings: Coronary Vessel Anomalies;Humans;Job Syndrome
Issue Date: Nov-2014
Publisher: INFORMA HEALTHCARE
Journal: Annals of medicine 
Abstract: 
Several lines of evidence demonstrate that the immune system plays a pivotal role in development and progression of ischemic heart disease (IHD). More recently, a series of biological and clinical investigations has generated new interest about the existence of a relationship between a specific class of immunoglobulin, that is immunoglobulin E (IgE), and IHD. Data obtained in several epidemiological studies have convincingly demonstrated that the concentration of total serum IgEs is significantly increased in patients with IHD and often correlates with the prognosis. The putative mechanisms are essentially mediated by a physiological interaction between IgEs and mast cells, which triggers the direct or indirect release of a variety of substances that are actively involved in the pathogenesis of myocardial ischemia and thrombosis. Regardless of these important evidences, a causality dilemma remains, since it is still unclear whether increased IgE levels are a consequence of IHD or, rather, IHD is an underlying cause of increased IgE levels. The answer would allow us to recognize whether total IgEs may be considered simple biomarkers or risk factors of IHD, thus paving the way to investigations focused on immunotherapy or avoidance of allergenic foods for reducing serum IgEs in patients at risk of IHD.
URI: http://hdl.handle.net/20.500.12857/126994
ISSN: 07853890
DOI: 10.3109/07853890.2014.927714
Appears in Collections:Articles

Show full item record

PubMed Central
Citations 50

4
Last Week
0
Last month
0
checked on Aug 7, 2021

SCOPUSTM   
Citations

20
checked on Sep 1, 2020

WEB OF SCIENCETM
Citations

22
checked on Nov 26, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.