Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/126996
Title: A review of the value of D-dimer testing for prediction of recurrent venous thromboembolism with increasing age
Authors: Lippi, Giuseppe 
Favaloro, Emmanuel J
Cervellin, Gianfranco 
Keywords: aging;D-dimer;older people;thrombosis;venous thromboembolism
Keywords Plus: DEEP-VEIN THROMBOSIS;CUTOFF VALUES;RISK;DIAGNOSIS;THRESHOLD;DURATION
Mesh headings: Aging;Fibrin Fibrinogen Degradation Products;Thrombosis;Venous Thromboembolism
Secondary Mesh headings: Age Factors;Aged;Aged, 80 and over;Humans;Middle Aged;Risk Factors
Issue Date: Sep-2014
Publisher: THIEME MEDICAL PUBL INC
Journal: Seminars in thrombosis and hemostasis 
Abstract: 
Recurrent thrombosis is a relatively frequent complication of venous thromboembolism (VTE) and represents an important cause of clinical and economic issues for health care systems worldwide. Rates of thrombosis increase with increasing age, with aging recognized to be a risk factor for thrombosis. Although D-dimer is now regarded as the biochemical gold standard for assisting the diagnosis of VTE and predicting the recurrent risk of thrombosis, the interpretation of D-dimer values with increasing age remains challenging due to many factors. These include the development of age-related changes in both the microcirculation and blood coagulation, which ultimately contribute to generate a hypercoagulable state and a gradual increase of D-dimer concentration with aging. Convincing evidence has now been provided that while D-dimer values may be effectively utilized for predicting the risk of recurrent thrombosis with increasing age, conventional cutoff values are inappropriate for older populations. In summary, analysis of the current scientific literature suggests that the adoption of age-dependent thresholds may increase the diagnostic effectiveness of this biomarker with increasing age.
URI: http://hdl.handle.net/20.500.12857/126996
ISSN: 00946176
DOI: 10.1055/s-0034-1384630
Appears in Collections:Articles

Show full item record

PubMed Central
Citations 50

4
Last Week
0
Last month
0
checked on Aug 7, 2021

SCOPUSTM   
Citations

18
checked on Sep 1, 2020

WEB OF SCIENCETM
Citations

16
checked on Nov 26, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.