Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/126997
Title: Of MIs and men--a historical perspective on the diagnostics of acute myocardial infarction
Authors: Cervellin, Gianfranco 
Lippi, Giuseppe 
Keywords: acute coronary syndrome;biomarkers;electrocardiogram;history;myocardial infarction
Keywords Plus: NUCLEAR-MAGNETIC-RESONANCE;ACUTE CORONARY SYNDROMES;ST-SEGMENT ELEVATION;EGYPTIAN MUMMIES;TROPONIN IMMUNOASSAYS;UNIVERSAL DEFINITION;ANGINA-PECTORIS;IMAGE-FORMATION;ARTERIES;HEART
Mesh headings: Myocardial Infarction
Secondary Mesh headings: Animals;Biomarkers;Echocardiography;Electrocardiography;Female;Heart;History, 16th Century;History, 17th Century;History, 18th Century;History, 19th Century;History, 20th Century;History, 21st Century;History, Ancient;Humans;Magnetic Resonance Imaging;Male;Radiography;Radionuclide Imaging
Issue Date: Jul-2014
Publisher: THIEME MEDICAL PUBL INC
Journal: Seminars in thrombosis and hemostasis 
Abstract: 
The history of myocardial infarction (MI) diagnostics has gone through a continuous evolution over the past century, when several new discoveries have contributed to remarkably increase the number of patients appropriately diagnosed with this condition. The tale "of MIs and Men" displays rather a long history, since atherosclerosis was found to be present in humans several centuries before modern civilization and the identification of the most prevalent risk factors. It was only at the end of the 19th century and at the beginning of the 20th century that the physicians acknowledged that MI is principally sustained by coronary thrombosis, and that the clinical picture of MI could be subsequently confirmed at autopsy. With the first description of the electrocardiogram (ECG) in the 1910s and 1920s, the history of modern MI diagnostics really began. Additional important discoveries followed, which are mainly represented by radiography, echocardiography, computed tomography, and magnetic resonance imaging of the heart. Another major breakthrough occurred at the down of the third millennium, with the development of commercial immunoassays for the measurement of cardiac troponin I and T, which represent now the cornerstones for identifying any kind of myocardial injury, thus including MI. The major advancements in the understanding of MI pathophysiology and the progressive introduction of efficient diagnostic tools will be described and discussed in this narrative historical review.
URI: http://hdl.handle.net/20.500.12857/126997
ISSN: 00946176
DOI: 10.1055/s-0034-1383544
Appears in Collections:Articles

Show full item record

PubMed Central
Citations 50

13
Last Week
0
Last month
0
checked on Jul 15, 2021

SCOPUSTM   
Citations

26
checked on Sep 1, 2020

WEB OF SCIENCETM
Citations

31
checked on Nov 26, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.