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|Title:||Adrenaline in anaphylaxis treatment. Balancing benefits and harms||Authors:||Cervellin, Gianfranco
|Keywords:||Adrenaline;allergy;anaphylaxis;epinephrine||Keywords Plus:||FOOD-INDUCED ANAPHYLAXIS;EMERGENCY-DEPARTMENT;ALLERGIC REACTIONS;UNITED-KINGDOM;EPINEPHRINE;GUIDELINES;HOSPITALIZATIONS;MANAGEMENT;FATALITIES;DIAGNOSIS||Mesh headings:||Anaphylaxis;Epinephrine;Vasoconstrictor Agents||Secondary Mesh headings:||Adrenergic Agonists;Emergency Treatment;Humans;Time Factors||Issue Date:||Jun-2016||Publisher:||TAYLOR & FRANCIS LTD||Journal:||Expert opinion on drug safety||Abstract:||
Although anaphylaxis is a relatively common disorder, clinicians and scientists have debated on how to best define and manage this condition. The current recommendations are focused on the central role of adrenaline, but evidence in support of this therapeutic approach is modest, mainly for the lack of well-designed trials. Conversely, serious adverse effects are commonly reported following adrenaline use, especially when given intravenously. These include hypertension, ventricular arrhythmias, myocardial infarction, pulmonary edema.
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