Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/127513
Title: Unexplored diversity and strain-level structure of the skin microbiome associated with psoriasis
Authors: Tett, Adrian
Pasolli, Edoardo
Farina, Stefania
Truong, Duy Tin
Asnicar, Francesco
Zolfo, Moreno
Beghini, Francesco
Armanini, Federica
Jousson, Olivier
De Sanctis, Veronica
Bertorelli, Roberto
Girolomoni, Giampiero 
Cristofolini, Mario
Segata, Nicola
Keywords Plus: INFLAMMATORY-BOWEL-DISEASE;STAPHYLOCOCCUS-EPIDERMIDIS;NECROTIZING ENTEROCOLITIS;BACTERIAL DIVERSITY;GUT MICROBIOTA;PAN-GENOME;COMMUNITY;ALIGNMENT;COMMENSAL;TOOL
Issue Date: 2017
Publisher: NATURE PUBLISHING GROUP
Journal: NPJ biofilms and microbiomes 
Abstract: 
Psoriasis is an immune-mediated inflammatory skin disease that has been associated with cutaneous microbial dysbiosis by culture-dependent investigations and rRNA community profiling. We applied, for the first time, high-resolution shotgun metagenomics to characterise the microbiome of psoriatic and unaffected skin from 28 individuals. We demonstrate psoriatic ear sites have a decreased diversity and psoriasis is associated with an increase in Staphylococcus, but overall the microbiomes of psoriatic and unaffected sites display few discriminative features at the species level. Finer strain-level analysis reveals strain heterogeneity colonisation and functional variability providing the intriguing hypothesis of psoriatic niche-specific strain adaptation or selection. Furthermore, we accessed the poorly characterised, but abundant, clades with limited sequence information in public databases, including uncharacterised Malassezia spp. These results highlight the skins hidden diversity and suggests strain-level variations could be key determinants of the psoriatic microbiome. This illustrates the need for high-resolution analyses, particularly when identifying therapeutic targets. This work provides a baseline for microbiome studies in relation to the pathogenesis of psoriasis.
URI: http://hdl.handle.net/20.500.12857/127513
ISSN: 2055-5008
DOI: 10.1038/s41522-017-0022-5
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