Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/127877
Title: Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells
Authors: Di Francesco, Luigia
Dovizio, Melania
Trenti, Annalisa 
Marcantoni, Emanuela
Moore, Ashleigh
O'Gaora, Peadar
McCarthy, Cathal
Tacconelli, Stefania
Bruno, Annalisa
Alberti, Sara
Gizzo, Salvatore 
Nardelli, Giovanni Battista 
Orso, Genny 
Belton, Orina
Trevisi, Lucia 
Dixon, Dan A
Patrignani, Paola
Keywords Plus: CYCLOOXYGENASE ACTIVITY;VASCULAR DYSFUNCTION;METABOLIC MEMORY;CONCISE GUIDE;PHARMACOLOGY;MECHANISMS;INHIBITION;PLATELET;PROLIFERATION;PROSTACYCLIN
Issue Date: Sep-2015
Publisher: WILEY
Journal: British journal of pharmacology 
Abstract: 
Hyperglycaemic memory describes the progression of diabetic complications during subsequent periods of improved glycaemia. We addressed the hypothesis that transient hyperglycaemia causes aberrant COX-2 expression in HUVEC in response to IL-1β through the induction of long-lasting epigenetic changes involving microRNA-16 (miR-16), a post-transcriptional modulator of COX-2 expression.
URI: http://hdl.handle.net/20.500.12857/127877
ISSN: 00071188
DOI: 10.1111/bph.13241
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