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Title: Soft Tissue Tumors Rarely Presenting Primary in Bone; Diagnostic Pitfalls
Authors: Sbaraglia, Marta 
Righi, Alberto
Gambarotti, Marco
Vanel, Daniel
Picci, Piero
Dei Tos, Angelo P
Keywords: Hemangiopericytoma;Leiomyosarcoma of bone;Malignant fibrous histiocytoma;Primary sarcoma of bone;Synovial sarcoma of bone
Mesh headings: Bone Neoplasms;Fibroma;Histiocytoma, Malignant Fibrous;Osteosarcoma;Sarcoma
Secondary Mesh headings: Humans
Issue Date: Sep-2017
Journal: Surgical pathology clinics 
Primary bone sarcomas represent extremely rare entities. The use of now abolished labels, such as malignant fibrous histiocytoma and hemangiopericytoma, has significantly hampered the chance of identifying specific entities. It is now accepted that a broad variety of mesenchymal malignancies most often arising on the soft tissue may actually present as primary bone lesions. A more accurate morphologic partition is justified based on availability of distinct therapeutic options. An integrated diagnostic approach represents the only way to achieve a correct classification. In consideration of the significant complexity, primary bone sarcomas should ideally be handled in the context of expert centers.
ISSN: 18759181
DOI: 10.1016/j.path.2017.04.013
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