Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/182970
Title: Morphometric analysis of the canal system of cortical bone: An experimental study in the rabbit femur carried out with standard histology and micro-CT
Authors: Pazzaglia, U E
Zarattini, G
Giacomini, Dario 
Rodella, L
Menti, Anna Michela 
Feltrin, Giuseppe 
Keywords Plus: LONG BONES;MECHANICAL FUNCTION;HAVERSIAN SYSTEMS;OSTEON CLOSURE;3D STRUCTURE;PRESSURE;CIRCULATION;MIDSHAFT;POROSITY;ANATOMY
Mesh headings: Femur;Haversian System
Secondary Mesh headings: Animals;Body Weights and Measures;Bone Remodeling;Diaphyses;Rabbits;X-Ray Microtomography
Issue Date: Feb-2010
Publisher: WILEY-BLACKWELL PUBLISHING, INC
Journal: Anatomia, histologia, embryologia 
Abstract: 
The osteonal pattern of cortical bone is gradually built around the intracortical vessels by the progression of the cutting cones (secondary remodelling); therefore, the central canal size can be used as index of the remodelling activity. An experimental model in the rabbit femur was used to investigate, through central canal morphometry and frequency distribution analysis, the remodelling activity, comparing the middle of the diaphysis (mid-shaft) with the extremity (distal-shaft) and at the same level sectors and layers of the cortex in transversal sections. The study documented a higher density of canals in the mid-shaft than in the distal-shaft and a higher remodelling in the distal-shaft. There were no significant differences between dorsal, ventral, medial and lateral sectors at both mid-shaft and distal-shaft levels, while the number of canals was higher in the sub-periosteal layers than in the sub-endosteal. A lower threshold of 40 microm(2) was observed in the central canal area. Sealed osteons in the midshaft were 22.43% of the total number of osteons of the central canal area between 40 and 200 microm(2) and 0.44% of those of the distal-shaft. Micro-CT allowed a 3D reconstruction of the vascular canal system, which confirmed the branched network pattern rather than the trim architecture of the traditional representation. Some aspects like the lower threshold of the central canal size and the sealed osteons documented the plasticity of the system and its capacity for adaptation to changes in the haemodynamic conditions.
URI: http://hdl.handle.net/20.500.12857/182970
ISSN: 03402096
DOI: 10.1111/j.1439-0264.2009.00973.x
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