Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/182977
Title: Regulation of energy intake and mechanisms of metabolic adaptation or maladaptation after caloric restriction
Authors: Di Vincenzo, Angelo 
Di Vincenzo, Angelo
Maffei, Pietro
Rossato, Marco
Keywords: Adipocytes;Calorie restriction;Energy intake;Food intake;Metabolic adaptation
Keywords Plus: WEIGHT-GAIN
Issue Date: Sep-2020
Publisher: SPRINGER
Journal: Reviews in endocrine & metabolic disorders 
Abstract: 
Despite their critical role in susceptibility to metabolic diseases such as obesity and type 2 diabetes, mechanisms regulating energy balance are extremely complex and far from being fully understood. Both central and peripheral feedback circuits are involved and, despite it was traditionally thought that the energy balance of an organism depends on the equality between calorie intake within the system and energy expenditure, the regulation of energy content in biological systems oversteps the classical physical laws of thermodynamics. The fine-tuned mechanism for body weight and energy storage regulation is aimed to preserve survival chances in response to the variations of energy availability, as expressed by the metabolic flexibility of this system adapting subjects to both starvation and overfeeding. However, these mechanisms can lose their flexibility, with consequent maladaptation to both increased energy intake and calorie restriction leading to the development of several metabolic disturbances.
URI: http://hdl.handle.net/20.500.12857/182977
ISSN: 13899155
DOI: 10.1007/s11154-020-09565-6
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