Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/182980
Title: A rationale for targeting the P2X7 receptor in Coronavirus disease 19
Authors: Di Virgilio, Francesco
Tang, Yong
Sarti, Alba Clara
Rossato, Marco 
Keywords Plus: CONCISE GUIDE;DAMPS
Mesh headings: Coronavirus Infections;Pneumonia, Viral;Receptors, Purinergic P2X7;Respiratory Distress Syndrome
Secondary Mesh headings: Animals;Betacoronavirus;COVID-19;Cytokine Release Syndrome;Humans;Macrophages;Pandemics;SARS-CoV-2;T-Lymphocytes
Issue Date: 2020
Publisher: WILEY
Journal: British journal of pharmacology 
Abstract: 
Severe pneumonia which shares several of the features of acute respiratory distress syndrome (ARDS) is the main cause of morbidity and mortality in Coronavirus disease 19 (Covid-19) for which there is no effective treatment, so far. ARDS is caused and sustained by an uncontrolled inflammatory activation characterized by a massive release of cytokines (cytokine storm), diffuse lung oedema, inflammatory cell infiltration, and disseminated coagulation. Macrophage and T lymphocyte dysfunction plays a central role in this syndrome. In several experimental in vitro and in vivo models, many of these pathophysiological changes are triggered by stimulation of the P2X7 receptor. We hypothesize that this receptor might be an ideal candidate to target in Covid-19-associated severe pneumonia. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc.
URI: http://hdl.handle.net/20.500.12857/182980
ISSN: 00071188
DOI: 10.1111/bph.15138
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