Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/182990
Title: Default mode network activity in bipolar disorder
Authors: Zovetti, Niccolò
Rossetti, Maria Gloria 
Perlini, Cinzia 
Maggioni, Eleonora
Bontempi, Pietro 
Bellani, Marcella 
Brambilla, Paolo
Keywords: Bipolar disorder;default mode network;resting-state fMRI;review
Keywords Plus: STATE FUNCTIONAL CONNECTIVITY;RESTING-STATE;BRAIN;DEPRESSION;UNIPOLAR;METAANALYSIS;VARIABILITY;CORTEX
Mesh headings: Bipolar Disorder;Brain;Brain Mapping;Magnetic Resonance Imaging;Nerve Net;Neural Pathways
Secondary Mesh headings: Humans
Issue Date: 8-Sep-2020
Publisher: CAMBRIDGE UNIV PRESS
Journal: Epidemiology and psychiatric sciences 
Abstract: 
Since its discovery in 1997, the default mode network (DMN) and its components have been extensively studied in both healthy individuals and psychiatric patients. Several studies have investigated possible DMN alterations in specific mental conditions such as bipolar disorder (BD). In this review, we describe current evidence from resting-state functional magnetic resonance imaging studies with the aim to understand possible changes in the functioning of the DMN in BD. Overall, several types of analyses including seed-based and independent component have been conducted on heterogeneous groups of patients highlighting different results. Despite the differences, findings seem to indicate that BD is associated with alterations in both frontal and posterior DMN structures, mainly in the prefrontal, posterior cingulate and inferior parietal cortices. We conclude this review by suggesting possible future research directions.
URI: http://hdl.handle.net/20.500.12857/182990
ISSN: 20457960
DOI: 10.1017/S2045796020000803
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