Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12857/183004
Title: The impact of candidate influenza virus and egg-based manufacture on vaccine effectiveness: Literature review and expert consensus
Authors: Rajaram, Sankarasubramanian
Wojcik, Radek
Moore, Catherine
Ortiz de Lejarazu, Raúl
de Lusignan, Simon
Montomoli, Emanuele
Rossi, Alessandro
Pérez-Rubio, Alberto
Trilla, Antoni
Baldo, Vincenzo 
Jandhyala, Ravi
Kassianos, George
Keywords: Antigenic drift;Egg-adaptations;Influenza;Manufacturing;Vaccine
Keywords Plus: LABORATORY-CONFIRMED INFLUENZA;AMINO-ACID SUBSTITUTIONS;A H1N1 VIRUS;ANTIGENIC DRIFT;PANDEMIC INFLUENZA;A/H3N2 VIRUSES;B VIRUSES;MOLECULAR CHARACTERIZATION;BACTERIAL PNEUMONIA;SURVEILLANCE SCHEME
Issue Date: 27-Aug-2020
Publisher: ELSEVIER SCI LTD
Journal: Vaccine 
Abstract: 
Influenza is associated with significant morbidity and mortality worldwide. Whilst vaccination is key for the prevention of influenza infection, there are many factors which may contribute to reduced vaccine effectiveness, including antigenic evolution via both antigenic drift and egg-adaptations. Due to the currently dissociated and indirect evidence supporting both the occurrence of these two phenomena in the egg-based manufacturing process and their effects on vaccine effectiveness, this topic remains a subject of debate.
URI: http://hdl.handle.net/20.500.12857/183004
ISSN: 0264410X
DOI: 10.1016/j.vaccine.2020.06.021
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