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|Title:||The impact of candidate influenza virus and egg-based manufacture on vaccine effectiveness: Literature review and expert consensus||Authors:||Rajaram, Sankarasubramanian
Ortiz de Lejarazu, Raúl
de Lusignan, Simon
|Keywords:||Antigenic drift;Egg-adaptations;Influenza;Manufacturing;Vaccine||Keywords Plus:||LABORATORY-CONFIRMED INFLUENZA;AMINO-ACID SUBSTITUTIONS;A H1N1 VIRUS;ANTIGENIC DRIFT;PANDEMIC INFLUENZA;A/H3N2 VIRUSES;B VIRUSES;MOLECULAR CHARACTERIZATION;BACTERIAL PNEUMONIA;SURVEILLANCE SCHEME||Issue Date:||27-Aug-2020||Publisher:||ELSEVIER SCI LTD||Journal:||Vaccine||Abstract:||
Influenza is associated with significant morbidity and mortality worldwide. Whilst vaccination is key for the prevention of influenza infection, there are many factors which may contribute to reduced vaccine effectiveness, including antigenic evolution via both antigenic drift and egg-adaptations. Due to the currently dissociated and indirect evidence supporting both the occurrence of these two phenomena in the egg-based manufacturing process and their effects on vaccine effectiveness, this topic remains a subject of debate.
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